Strategies in Preventing Diabetes after Pancreatectomy Using Islet Auto- and Allo-Transplantation
نویسندگان
چکیده
منابع مشابه
Total Pancreatectomy and Islet Auto Transplantation for Chronic Pancreatitis
Surgical management of chronic pancreatitis is in a constant state of evolution. The trials of management are akin to the inherent complexity of the organ’s function and closeness to neighboring organs. As the progressive and irreversible process of chronic pancreatitis commences, patients are subjected to varying degrees of endocrine and exocrine loss, as well as pain. Management of this proce...
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Encapsulation of tissue has been an area of intense research with a myriad number of therapeutic applications as diverse as cancer, tissue regeneration, and diabetes. In the case of diabetes, transplantation of pancreatic islets of Langerhans containing insulin-producing beta cells has shown promise toward a cure. However, anti-rejection therapy that is needed to sustain the transplanted tissue...
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Allogeneic islet transplantation is a promising approach for restoring normoglycemia in type 1 diabetic patients. Current use of immunosuppressive therapies for management of islet transplant recipients can be counterintuitive to islet function and can lead to complications in the long term. The induction of donor-specific tolerance eliminates the dependency on immunosuppression and allows reci...
متن کاملIntroducing a New Experimental Islet Transplantation Model using Biomimetic Hydrogel and a Simple High Yield Islet Isolation Technique
Background: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus (T1DM). This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functi...
متن کاملIslet Transplantation in Type I Diabetes Mellitus
For most patients with type I diabetes, insulin therapy and glucose monitoring are sufficient to maintain glycemic control. However, hypoglycemia is a potentially lethal side effect of insulin treatment in patients who are glycemically labile or have hypoglycemia-associated autonomic failure [1]. For those patients, an alternative therapy is beta cell replacement via pancreas or islet transplan...
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ژورنال
عنوان ژورنال: International Journal of Transplantation Research and Medicine
سال: 2017
ISSN: 2572-4045
DOI: 10.23937/2572-4045.1510029